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IV tPA (IV thrombolytic) was not initiated at this hospital (even if there are documented contraindications or warnings to IV tPA) OR unable to determine from medical record documentation.

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Preliminary positron emission tomography (PET) scans after LSVT training in patients with Parkinson disease show reduced activity in the globus pallidus, an effect similar to pallidotomy.

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The addition of low-dose deprenyl to low-dose l-dopa usually results in a rather alarming adverse reaction, often after a delay of a week or two after the combination is begun.

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To test the safety of rasagiline, challenges with tyramine 50 to 75 mg were performed in 72 rasagiline-treated and 38 placebo-treated PD patients at the end of two double-blind, placebo-controlled trials (TEMPO and PRESTO; see page 604).

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Although ALA has been well-studied and found to be safe at standard doses in humans (typically 300-600mg), it is not known whether similar negative effects could occur with long term high-dosage supplementation.

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In an in vivo animal model used to test for antidepressant activity (Forced Swim Test), selegiline administered by transdermal patch exhibited antidepressant properties only at doses that inhibited both MAO-A and MAO-B activity in the brain.

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Rasagiline is used to treat the symptoms of Parkinson's disease (stiffness, tremors, spasms, poor muscle control).

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PD) is a progressive neurodegenerative, dopamine deficiency disorder.

Added: Limited life expectancy, severe co-morbid conditions, and CMO status all need to be explicitly documented as the reason for no IV tPA.

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If a Modified Rankin Score was not done because the hospital was notified of the patient's death prior to the interview call or visit, select the date of the notification for the Modified Rankin Score Date.

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The recommended regimen for the administration of ELDEPRYL is 10 mg per day administered as divided doses of 5 mg each taken at breakfast and lunch.

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The development of adverse effects and changes in the steady response to medications pose numerous challenges to patients, their families, and health care providers.

REQUIRED FOR COMPREHENSIVE: What is the highest NIHSS score documented within 36 hours following initiation of IV (t-PA) thrombolytic therapy?

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The tremor associated with PD typically takes the form of a rhythmic back-and-forth motion of the thumb and forefinger at three beats per second.

However, there is some controversy about waiting to begin treatment with levodopa because it can be so beneficial.

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To lower this risk, remain sitting or lying down after using this medication.

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It has therefore been suggested that people taking 30 mg or more of selegiline per day should consume a tyramine-free diet.

Regardless of the type of cognitive changes experienced, accurate assessment is essential if symptoms are to be treated.

Selegiline was approved for use in the United States in 2006, the first MAO-B inhibitor approved for use in the therapy of Parkinson disease as an adjunct to levodopa therapy.

Both drugs are indicated as adjunctive therapy to levodopa; only rasagiline is approved as monotherapy.

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Since dyskinesia was much more common in the levodopa group (45 percent) than in the ropinirole group (20 percent), a lower rate of supplementation in the levodopa group may have resulted.

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The disorders known collectively as "pediatric neurotransmitter disorders" consist of several possibly under-recognized, recently identified errors of metabolism that affect the production of neurotransmitters.

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